EGFR probes matrix stiffness

Coupled Bending-Longitudinal Vibration of Three Layer Sandwich Beam using Exact Dynamic Stiffness Matrix

A Newtonian (vectorial) approach is used to develop the governing differential equations of motion for a three layer sandwich beam in which the uniform distribution of mass and stiffness is dealt with exactly. The model allows for each layer of material to be of unequal thickness and the effects of coupled bending and longitudinal motion are accounted for. This results in an eighth order ordina...

Organ sculpting by patterned extracellular matrix stiffness

How organ-shaping mechanical imbalances are generated is a central question of morphogenesis, with existing paradigms focusing on asymmetric force generation within cells. We show here that organs can be sculpted instead by patterning anisotropic resistance within their extracellular matrix (ECM). Using direct biophysical measurements of elongating Drosophila egg chambers, we document robust me...

Investigation of Utilizing a Secant Stiffness Matrix for 2D Nonlinear Shape Optimization and Sensitivity Analysis

In this article the general non-symmetric parametric form of the incremental secant stiffness matrix for nonlinear analysis of solids have been investigated to present a semi analytical sensitivity analysis approach for geometric nonlinear shape optimization. To approach this aim the analytical formulas of secant stiffness matrix are presented. The models were validated and used to perform inve...

EGFR in Enamel Matrix Derivative-induced gingival fibroblast mitogenesis.

We previously reported that EMD (Enamel Matrix Derivative) induces proliferation of human gingival fibroblasts via activation of Extracellular Regulated Kinase (ERK), and this study assessed the possible mediatory role of EGFR (Epidermal Growth Factor Receptor) in this effect. Treatment of gingival fibroblasts with EMD resulted in tyrosine phosphorylation of the EGFR, as assessed by immunoblott...

Aortic Stiffness and Inflammation: Dyslipidemia or Matrix Metalloproteinases?